CAS: 106-24-1
FEMA No: 2507
Geraniol has a sweet, floral, fruity, rosy, waxy, citrus smell to it. The terpene has been known as a good mosquito repellent, but unfortunately attracts bees. Geraniol is toxic to bacteria and certain fugi. Further uses for the terpene include anti-inflammatory action. Also as a topical drug enhancer and anti-inflammatory, geraniol has proven useful.
ATTRIBUTES
Sources
Rose, Lemongrass, Citronella
Aroma
Citrus, Floral, Fruity, Rosy, Sweet, Waxy
Flavor Profile
Geranium, Lemon Peel, Passion Fruit, Peach, Rose
Benefit
Analgesic, Anti-bacterial, Anti-inflammatory, Antifungal, Topical Drug Enhancer
Research
Analgesic
The effects of Geraniol on relieving pain were investigated in mice. Upon administration, geraniol significantly affected the number of Fos-positive cells in pain neuron sites in the brain, signifying an analgesic outcome.
Anti-fungal
Geraniol was examined as a fungicide for Candida albicans. Administration of the compound inhibited pseudohyphae and chlamydoconidia formation of the fungus. In the time-dependent kill curve assay, fungicidal activity for MIC × 2 started at 2 h for the ATCC 76485 strain, and at 4 h for the LM-70 strain..
- Investigating the antifungal activity and mechanism(s) of geraniol against Candida albicans strains.
- Chemical composition, cytotoxicity and in vitro antitrypanosomal and antiplasmodial activity of the essential oils of four Cymbopogon species from Benin.
- Protective antifungal activity of essential oils extracted from Buddleja perfoliata and Pelargonium graveolens against fungi isolated from stored grains.
Anti-bacterial
Geraniol has been confirmed to be toxic against several bacteria species, Escherichia coli O157 : H7(VT(-)), Clostridium difficile DSM1296, Clostridium perfringens DSM11780, Salmonella typhimurium 3530 Salmonella enteritidis S1400, and Staphylococcus aureus
- Antibacterial Investigation of Thyme Essential Oil and Its Main Constituents in Combination with Tetracycline.
- Sensitivity of pathogenic and commensal bacteria from the human colon to essential oils.
- Essential oils from aromatic herbs as antimicrobial agents.
- Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level.
Topical drug enhancer
Geraniol co-application with a couple topical drugs was concluded to enhance the skin penetration in delivering these medicines in mice.
Anti-inflammatory
BALB/c mice were induced to have an inflammatory response by treating with
aminobisphosphonate alendronate and bacterial muramyldipeptide. Geraniol, and geranylgeraniol were effective in preventing the inflammation induced by alendronate-muramyldipeptide. This could be an effective treatment for mevalonate kinase deficiency.
Cannabis
Common strains high in Geraniol
Most strains
SCIENCE
- Formula: C10H18O
- Molecular Mass: 154.25 g/mol
- Relative Density: 0.879 g/mL g/mL at 20 C
- Water Solubility: 0.1 g/l at 25 C
- Melting Point: -15 C
- Boiling Point: 229 C
- Flash Point: 108 C
Synonyms
Geraniol is also know by these other names
106-24-1 [RN]
3,7-Dimethylocta-2,6-dien-1-ol
(2E)-3,7-Dimethyl-2,6-octadienol
2,6-octadien-1-ol, 3,7-dimethyl-
(2E)-3,7-Dimethylocta-2,6-dien-1-ol
(2E)-3,7-Dimethyl-2,6-octadien-1-ol [ACD/IUPAC Name]
2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)- [ACD/Index Name]
SAFETY
LD50: Rat - 3,600 mg/kg
Storage: Room temperature, proper ventilation, spark proof environment
DANGER
Causes skin irritation and may cause an allergic skin reaction. Causes serious eye damage. Avoid breathing dust / fume / gas / mist / vapours / spray. Wash skin thoroughly after handling. Contaminated work clothing should not be allowed out of the workplace. Avoid release to the environment. Wear eye protection / face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor / physician. If skin irritation or rash occurs: Get medical advice / attention. Take off contaminated clothing and wash before reuse. Harmful to aquatic life. Dispose of contents / container to an approved waste disposal plant.
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