Geraniol

CAS: 106-24-1
FEMA No: 2507

Geraniol Molecule

Geraniol has a sweet, floral, fruity, rosy, waxy, citrus smell to it. The terpene has been known as a good mosquito repellent, but unfortunately attracts bees. Geraniol is toxic to bacteria and certain fugi. Further uses for the terpene include anti-inflammatory action. Also as a topical drug enhancer and anti-inflammatory, geraniol has proven useful.

ATTRIBUTES

Sources

Rose, Lemongrass, Citronella

Aroma

Citrus, Floral, Fruity, Rosy, Sweet, Waxy

Flavor Profile

Geranium, Lemon Peel, Passion Fruit, Peach, Rose

Benefit

Analgesic, Anti-bacterial, Anti-inflammatory, Antifungal, Topical Drug Enhancer

Research

Analgesic

The effects of Geraniol on relieving pain were investigated in mice. Upon administration, geraniol significantly affected the number of Fos-positive cells in pain neuron sites in the brain, signifying an analgesic outcome.

Anti-fungal

Geraniol was examined as a fungicide for Candida albicans. Administration of the compound inhibited pseudohyphae and chlamydoconidia formation of the fungus. In the time-dependent kill curve assay, fungicidal activity for MIC × 2 started at 2 h for the ATCC 76485 strain, and at 4 h for the LM-70 strain..

Anti-bacterial

Geraniol has been confirmed to be toxic against several bacteria species, Escherichia coli O157 : H7(VT(-)), Clostridium difficile DSM1296, Clostridium perfringens DSM11780, Salmonella typhimurium 3530 Salmonella enteritidis S1400, and Staphylococcus aureus

Topical drug enhancer

Geraniol co-application with a couple topical drugs was concluded to enhance the skin penetration in delivering these medicines in mice.

Anti-inflammatory

BALB/c mice were induced to have an inflammatory response by treating with
aminobisphosphonate alendronate and bacterial muramyldipeptide. Geraniol, and geranylgeraniol were effective in preventing the inflammation induced by alendronate-muramyldipeptide. This could be an effective treatment for mevalonate kinase deficiency.

Cannabis

Common strains high in Geraniol

Most strains

SCIENCE

Monoterpene

  • Formula: C10H18O
  • Molecular Mass: 154.25 g/mol
  • Relative Density: 0.879 g/mL g/mL at 20 C
  • Water Solubility: 0.1 g/l at 25 C
  • Melting Point: -15 C
  • Boiling Point: 229 C
  • Flash Point: 108 C

Synonyms

Geraniol is also know by these other names

106-24-1 [RN]

3,7-Dimethylocta-2,6-dien-1-ol

(2E)-3,7-Dimethyl-2,6-octadienol

2,6-octadien-1-ol, 3,7-dimethyl-

(2E)-3,7-Dimethylocta-2,6-dien-1-ol

(2E)-3,7-Dimethyl-2,6-octadien-1-ol [ACD/IUPAC Name]

2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)- [ACD/Index Name]

SAFETY

LD50: Rat - 3,600 mg/kg

Storage: Room temperature, proper ventilation, spark proof environment

DANGER

Causes skin irritation and may cause an allergic skin reaction. Causes serious eye damage. Avoid breathing dust / fume / gas / mist / vapours / spray. Wash skin thoroughly after handling. Contaminated work clothing should not be allowed out of the workplace. Avoid release to the environment. Wear eye protection / face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor / physician. If skin irritation or rash occurs: Get medical advice / attention. Take off contaminated clothing and wash before reuse. Harmful to aquatic life. Dispose of contents / container to an approved waste disposal plant.

DISCUSSION

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