Myrcene

CAS: 123-25-3
FEMA No: 2762

Myrcene Molecule

Myrcene is a monoterpene and an important precursor to many terpenes. It has a woody, vegetative, citrus, fruity, and mango-like scent. Myrcene is hypothesised to help compounds enter cells through enhancing membrane permeation. Myrcene has been shown to be an analgesic in mice and did not cause tolerance to the effect. Ther terpene is also noted to have antioxidant effects with mutagenic compounds. Another benefit to myrcene is its ability to relax muscles and induce sleep.

ATTRIBUTES

Sources

Myrcia, Bay Tree, Mango, Ylang-ylang, Wild Thyme, Parsley, Hops, Houttuynia, Verbena

Aroma

Balsam, Peppery, Spicy

Flavor Profile

Balsamic, Fruit, Geranium, Herb, Must

Benefit

Analgesic, Antioxidant, Sedative

Research

Analgesic

Oral administration of myrcene in rats was concluded to produce a dose-dependent pain relief for the hyperalgesia induced by subplantar injections of either carrageenin or prostaglandin E2, but did not affect that induced by dibutyryl cyclic AMP. These results indicated a peripheral site of action. In contrast to the central analgesic effect of morphine, myrcene did not cause tolerance on repeated dosing in rats. Myrcene shows promise as a lead for the development of new peripheral pain killers with a different method of action than aspirin-like drugs.

Sedative

Myrcene was explored as a sedative in the mouse model. Muscle relaxation was seen as observed through the rota rod test. In addition there was an increase in sleeping time by 2.6x.

Antioxidant

Myrcene was eluted to block the metabolic activation of some promutagens (e.g., cyclophosphamide and aflatoxin B1) in in vitro genotoxicity assays. The effects of myrcene was evaluated through the activity of liver microsomes. A concentration-dependent competitive inhibition was observed for pentoxyresorufin -O-depenthylase activity, a selective marker for a cytochrome p450. The potent inhibitory effects on the cytochrome p450 suggest that myrcene, could also interfere with the metabolism of xenobiotics, which are substrates for this isoenzyme

synergy

Synergistic effects with…

Cannabinoids

Analgesic - CBD, THC
Sedative - THC, CBN
Anti-oxidant - CBD, CBG

Other Terpenes

Sedative - nerolidol

Cannabis

Common strains high in Myrcene

Arjan's strawberry haze 30.05
Big bang 25.11
El nino 38.71
Great white shark 26.97
Himalayan gold 21.56
Jack herer 34.10
Kalashnikova 33.29
NL5 haze mist 37.57
Pure kush 31.40
Superbud 33.29
The church 25.04

SCIENCE

Monoterpene

  • Formula: C10H16
  • Molecular Mass: 136.23 g/mol
  • Relative Density: 0.801g/mL
  • Water Solubility: 0.00109 g/L at 20 C
  • Auto-ignition Temp: 255 C
  • Melting Point: < -80 C
  • Boiling Point: 167 C
  • Flash Point: 44 C

Synonyms

Myrcene is also know by these other names

  • β-Myrcene
  • 123-35-3 [RN]
  • b-Geraniolene
  • 7-methyl-3-methyleneocta-1,6-diene
  • 7-methyl-3-methylideneocta-1,6-diene
  • 7-Methyl-3-methylene-1,6-octadiene [ACD/IUPAC Name]
  • 1,6-Octadiene, 7-methyl-3-methylene- [ACD/Index Name]

SAFETY

LD50: > 5,000 mg/kg

Storage: 2 – 8 C, proper ventilation, spark proof environment.

DANGER

Flammable liquid and vapor. Store in a well-ventilated place. Keep cool. Store locked up. Keep away from heat / sparks / open flames / hot surfaces. No smoking. Keep container tightly closed. Ground / bond container and receiving equipment. Use explosion-proof electrical / ventilating / lighting / equipment. Use only non-sparking tools. Take precautionary measures against static discharge. In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction. May be fatal if swallowed and enters airways. Causes skin and serious eye irritation. Wash skin thoroughly after handling. Wear protective gloves / protective clothing / eye protection / face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor / physician. IF ON SKIN (or hair): Remove / Take off immediately all contaminated clothing. Rinse skin with water / shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Do NOT induce vomiting. If skin irritation occurs: Get medical advice / attention. If eye irritation persists: Get medical advice / attention. Take off contaminated clothing and wash before reuse. Dispose of contents / container to an approved waste disposal plant.

DISCUSSION

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