Terpinolene

CAS: 586-62-9
FEMA No: 3046

Terpinolene Molecule

Terpinolene is a common terpene primarily isolated from trees. It is present in high amounts in terpintine, which is used in the construction business as well. Terpinolene also goes by the name delta terpinene.

Terpinolene is not an analgesic or an anti-inflammatory, yet most cannabinoids and terpenoids are one of the two or both.

Terpinolene was concluded to be effective against several species of bacteria. Terpinolene is able to increase total antioxidant capacity levels in white blood cells without changing the total oxidative stress level. Terpinolene is further effective in fighting glial cell cancer and leukemia.

ATTRIBUTES

Sources

Apple, Cumin, Lilac, Tea Tree, Pine, Fir

Aroma

Citrus, Fresh, Lemon, Piney, Sweet, Woody

Flavor Profile

Pine, Woody, Lemon, Herbal, Floral

Benefit

Anti-bacterial, Anti-cancer, Antioxidant, Sedative

Research

Antibacterial

Terpinolene was elucidated to be toxic against, Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli through the disk susceptibility test minimum inhibitory concentrations measurements in a couple studies.

Anti-oxidant

Genotoxic, oxidative and cytotoxic effects of terpinolene were explored with white blood cells. Genotoxicity was evaluated by micronucleus assay, sister chromatid exchanges assay, and 8-oxo-2-deoxyguanosine measurements. Cytotoxicity was detected by lactate dehydrogenase release and MTT assay. All assays were negative. Terpinolene treatment showed statistically significant increases of total antioxidant capacity levels in the cells without changing total oxidative stress levels. This antioxidant effect was also seen in preventing the oxidation of low density lipoprotein, which is helpful in combatting heart disease.

Sedative

Nasal transmission of terpinolene was concluded to induce sleep in mice. Oral administration may prove more potent.

Anti-cancer

A key protein involved in progressing cancers, RAC-alpha serine/threonine-protein kinase, was shown to be reduced in leukemia cells with the treatment of terpinolene. Also brain cancer cells were shown to be significantly affected by the terpene as well, and no signs of genetic damage were seen in the normal cells.

Insecticide

Terpinolene demonstrated toxic effects against cockroaches, Blattella germanica,through contact as well as a fumigant.

Cannabis

Common strains high in Terpinolene

Arjan’s haze #3 6.80

SCIENCE

Monoterpene

  • Formula: C10H16
  • Molecular Mass: 136.23 g/mol
  • Relative Density: 0.861 g/cm3
  • Water Solubility: 9.5 mg/L at 25 C
  • Boiling Point: 184 C
  • Flash Point: 64 C

Synonyms

Terpinolene is also know by these other names

  • δ-Terpinene
  • 586-62-9 [RN]
  • (±)-α-Terpinyl acetate
  • p-Meth-1-en-8-yl-formate
  • 4-Isopropylidéne-1-méthylcyclohexène
  • 1-Methyl-4-(2-propanyliden)cyclohexen
  • 4-Isopropylidene-1-methyl-cyclohexene
  • 1-Methyl-4-(propan-2-yliden)cyclohexen
  • 1-methyl-4-(propan-2-ylidene)cyclohexene
  • 4-Isopropylidene-1-methylcyclohexene [ACD/IUPAC Name]
  • Cyclohexene, 1-methyl-4-(1-methylethylidene)- [ACD/Index Name]

SAFETY

LD50: > 4,000 mg/kg

Storage: Room temperature, proper ventilation, spark proof environment.

WARNING

Combustible liquid. Store in a well-ventilated place. Keep cool. Keep away from heat / sparks / open flames / hot surfaces. No smoking. Avoid release to the environment. Wear protective gloves / protective clothing / eye protection / face protection. In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction. Collect spillage. Very toxic to aquatic life with long lasting effects. Dispose of contents / container to an approved waste disposal plant.

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