Caryophyllene Oxide

CAS: 1139-30-6
FEMA No: 4085

Caryophyllene Oxide Molecule

Caryophyllene oxide is an oxygenated terpenoid, usually a metabolic by product of caryophyllene. It’s use as an antifungal is highly effective with certain species. In addition, caryophyllene oxide has also been indicated as an anticoagulant with platelets



Lemon Balm, Black Caraway, Cloves, Hops, Basil, Oregano, Black Pepper, West African Pepper, Lavender, Rosemary, Cinnamomum, Malabathrum, Cananga Odorata, Copaiba Oil


Dry, Fresh, Spicy, Sweet, Woody

Flavor Profile

Herb, Must, Spice, Wood


Antifungal, Antocoagulant



Commonly used as preservative in food, drugs, and cosmetics. Its antifungal activity has been compared to ciclopiroxolamine and sulconazole, mainly used in onychomycosis treatment and dermatophytes.

Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis.


Caryophyllene oxide isolated from the rhizome of Formosan Gynura japonica was shown to exhibit significant anti-platelet aggregation activity in vitro.
Anti-Platelet Aggregation and Chemical Constituents from the Rhizome of Gynura japonica


Synergistic effects with…


Antifungal - CBC, CBG
Anticoagulant - THC
Insecticidal - THCA, CBGA


  • Formula: C15H24O
  • Molecular Mass: 220.35 g/mol
  • Melting Point: 60.00 C - 62.00 C
  • Boiling Point: 279.68 C
  • Flash Point: > 212.00 F


Caryophyllene Oxide is also know by these other names

  • 1139-30-6 [RN]
  • β-Caryophyllene oxide
  • b-Caryophyllene oxide
  • (−)-Epoxycaryophyllene
  • b-Caryophyllene epoxide
  • (−)-Caryophyllene oxide
  • 4b,5a-Epoxycaryophyllene
  • (-)-b-Caryophyllene oxide
  • Caryophyllene 4b,5a-oxide
  • trans-caryophyllene oxide
  • (-)-β-Caryophyllene epoxide
  • (-)-b-Caryophyllene epoxide
  • 6,7-Epoxy-3(15)-caryophyllene
  • (-)-Epoxydihydrocaryophyllene
  • (1R,4R,6R,10S)-4,12,12-trimethyl-9-methylene-5-oxatricyclo[,6]dodecane
  • 5-Oxatricyclo(,6))dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)-
  • (1R,4R,6R,10S)-4,12,12-Trimethyl-9-methylene-5-oxatricyclo[,6]dodecane [ACD/IUPAC Name]
  • 5-Oxatricyclo[,6]dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)- [ACD/Index Name]


LD50: Rat > 5,000 mg/kg

Storage: Store in cool, dry place in tightly sealed containers, protected from heat and light


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