FEMA No: 2507
Geraniol has a sweet, floral, fruity, rosy, waxy, citrus smell to it. The terpene has been known as a good mosquito repellent, but unfortunately attracts bees. Geraniol is toxic to bacteria and certain fugi. Further uses for the terpene include anti-inflammatory action. Also as a topical drug enhancer and anti-inflammatory, geraniol has proven useful.
Rose, Lemongrass, Citronella
Citrus, Floral, Fruity, Rosy, Sweet, Waxy
Geranium, Lemon Peel, Passion Fruit, Peach, Rose
Analgesic, Anti-bacterial, Anti-inflammatory, Antifungal, Topical Drug Enhancer
The effects of Geraniol on relieving pain were investigated in mice. Upon administration, geraniol significantly affected the number of Fos-positive cells in pain neuron sites in the brain, signifying an analgesic outcome.
Geraniol was examined as a fungicide for Candida albicans. Administration of the compound inhibited pseudohyphae and chlamydoconidia formation of the fungus. In the time-dependent kill curve assay, fungicidal activity for MIC × 2 started at 2 h for the ATCC 76485 strain, and at 4 h for the LM-70 strain..
- Investigating the antifungal activity and mechanism(s) of geraniol against Candida albicans strains.
- Chemical composition, cytotoxicity and in vitro antitrypanosomal and antiplasmodial activity of the essential oils of four Cymbopogon species from Benin.
- Protective antifungal activity of essential oils extracted from Buddleja perfoliata and Pelargonium graveolens against fungi isolated from stored grains.
Geraniol has been confirmed to be toxic against several bacteria species, Escherichia coli O157 : H7(VT(-)), Clostridium difficile DSM1296, Clostridium perfringens DSM11780, Salmonella typhimurium 3530 Salmonella enteritidis S1400, and Staphylococcus aureus
- Antibacterial Investigation of Thyme Essential Oil and Its Main Constituents in Combination with Tetracycline.
- Sensitivity of pathogenic and commensal bacteria from the human colon to essential oils.
- Essential oils from aromatic herbs as antimicrobial agents.
- Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level.
Topical drug enhancer
Geraniol co-application with a couple topical drugs was concluded to enhance the skin penetration in delivering these medicines in mice.
BALB/c mice were induced to have an inflammatory response by treating with
aminobisphosphonate alendronate and bacterial muramyldipeptide. Geraniol, and geranylgeraniol were effective in preventing the inflammation induced by alendronate-muramyldipeptide. This could be an effective treatment for mevalonate kinase deficiency.
Common strains high in Geraniol
- Formula: C10H18O
- Molecular Mass: 154.25 g/mol
- Relative Density: 0.879 g/mL g/mL at 20 C
- Water Solubility: 0.1 g/l at 25 C
- Melting Point: -15 C
- Boiling Point: 229 C
- Flash Point: 108 C
Geraniol is also know by these other names
(2E)-3,7-Dimethyl-2,6-octadien-1-ol [ACD/IUPAC Name]
2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)- [ACD/Index Name]
LD50: Rat - 3,600 mg/kg
Storage: Room temperature, proper ventilation, spark proof environment
Causes skin irritation and may cause an allergic skin reaction. Causes serious eye damage. Avoid breathing dust / fume / gas / mist / vapours / spray. Wash skin thoroughly after handling. Contaminated work clothing should not be allowed out of the workplace. Avoid release to the environment. Wear eye protection / face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor / physician. If skin irritation or rash occurs: Get medical advice / attention. Take off contaminated clothing and wash before reuse. Harmful to aquatic life. Dispose of contents / container to an approved waste disposal plant.
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