Linalool

CAS: 78-70-6
FEMA No: 2635

Linalool is a terpene alcohol with a citrusy, floral, sweet, bois de rose, woody, green, blueberry scent. Linalool is able to act on the opioidergic and cholinergic systems to relieve pain, a unique pathway for terpenes. Linalool also acts as an anticonvulsant, having similar effects to diazepam. Linalool has been used as a relaxant and as a treatment for anxiety for thousands of years. In scientific studies, linalool was proven to sedate mice and also mitigate anxiety.

ATTRIBUTES

Sources

Lamiaceae, Lauraceae, Birch Trees, Citrus

Aroma

Blueberry, Citrus, Floral, Rosy, Sweet, Woody

Flavor Profile

Coriander, Floral, Lavender, Lemon, Rose

Benefit

Analgesic, Anti-anxiety, Anti-inflammatory, Anticonvulsant, Sedative

Research

Anti-inflammatory

Linalool was able to reduce carrageenin-induced edema in rats, a classic model of inflammation. It’s acetate version was noted to have the same effect as well

• Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils

Analgesic

In mice exposed to acetic acid-induced writhing response and the hot plate test, linalool was able to act on the opioidergic and cholinergic systems in a manner to prevent neural networks from transmitting the signal of pain.

• (−)-Linalool produces antinociception in two experimental models of pain

Anticonvulsant

Linalool was eluted to possess pharmacological activity close to that of diazepam. In a PTZ model, PIC seizure mode, and tonic convulsions induced by transcorneal electroshock, linalool therapeutically decreased the convulsion time in mice

• Anticonvulsant activity of the linalool enantiomers and racemate: investigation of chiral influence.

Sedative

In an elevated plus maze test, linalool indicated to modulate motor movements and locomotion. At a high enough dose, linalool was able to make the mice go to sleep.

• Investigation of the anxiolytic effects of linalool, a lavender extract, in the male Sprague-Dawley rat.

Anti-anxiety

Linalool was shown to possess anxiolytic properties without any side effects, showing promising potential use in treatment of anxiety disorders. Linalool was evaluated on 4-week ICR mice using an open field test, a light-dark test and an elevated plus maze test. The measurements of monoamines in the brain showed decreased serotonin, dopamine, and norepinephrine, which is commonly seen in animal models exhibiting anxiolytic effects.

• Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice

synergy

Synergistic effects with…

Cannabinoids

Anti-anxiety - CBG
Sedative - CBN,THC
Analgesic - CBD
Anticonvulsant - CBD, CBDV, THCV

Other Terpenes

Anti-anxiety - limonene
GABA uptake inhibitor - phytol

Cannabis

Common strains high in Linalool

Chem dogg 2.83
Diamond girl 7.36
Gh cheeze 4.83
Gh skunk 3.62
Kaia kush 2.08
Kalashnakova 4.52
K-train 2.95
Superbud 4.47

SCIENCE

Monoterpene

• Formula: C10H18O
• Molecular Mass: 154.25 g/mol
• Relative Density: 0.858 g/mL
• Water Solubility: 1.589 g/L
• Auto-ignition Temp: 260 C
• Melting Point: < -74 C
• Boiling Point: 198 C
• Flash Point: 78 C

Synonyms

Linalool is also know by these other names

• β-Linalool
• Linalool, β
• dl-Linalool
• (±)-Linalool
• 78-70-6 [RN]
• allo-Ocimenol
• linalyl alcohol
• 245-083-6 [EINECS]
• 3,7-Dimethylocta-1,6-dien-3-ol
• 3,7-Dimethyl-1,6-octadien-3-ol [ACD/IUPAC Name]
• 1,6-Octadien-3-ol, 3,7-dimethyl- [ACD/Index Name]

SAFETY

LD50: Mice - 3,000 mg/kg

Storage: 2 – 8 C, proper ventilation, spark proof environment.

WARNING

Combustible liquid. Store in a well-ventilated place. Keep cool. Keep away from heat / sparks / open flames / hot surfaces. No smoking. In case of fire: Use appropriate media to extinguish. May be harmful if swallowed. Harmful in contact with skin. Causes skin and serious eye irritation. Wash thoroughly after handling. Avoid release to the environment. Wear protective gloves / protective clothing / eye protection / face protection. IF ON SKIN: Wash with plenty of water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER / doctor if you feel unwell. If skin irritation occurs: Get medical advice / attention. If eye irritation persists:Get medical advice / attention. Take off contaminated clothing and wash it before reuse. Harmful to aquatic life. Dispose of contents / container in accordance with local / regional / national / international regulations.

DISCUSSION

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